Ibisobanuro bigufi:
Numero ya CAS: 55268-74-1
Inzira ya molekulari: C.19H24N2O2
uburemere bwa molekile: 312.41
Imiterere ya shimi ：
| Amakuru Yibanze | |
| Izina RY'IGICURUZWA | Praziquantel |
| Icyiciro | Icyiciro cya Farma |
| Kugaragara | Nifu ya pisitori yera cyangwa hafi yera |
| Suzuma | 99% |
| Ubuzima bwa Shelf | Imyaka 2 |
| Gupakira | 25kg / ingoma |
| Ibiranga | Kubora kubusa muri Ethanol cyangwa dichloromethane.Gushonga buhoro mumazi |
| Imiterere | Ikidodo cyumye, Ubike muri firigo, munsi ya -20 ° C. |
Ibisobanuro
Praziquantel (PZQ) ni inkomoko ya isoquinoline hamwe nibikorwa byinshi byibinyabuzima biboneka muri levo enantiomer.Urusange ntirukora ibikorwa bya nematode, ariko rufite akamaro kanini kurwanya cestode na trematode.
Farumasi nuburyo bwibikorwa
Praziquantel ni uruganda rwa pyrazinoquinoline rwatunganijwe mbere yo kuvura schistosomiasis ariko byagaragaye ko rufite ibikorwa byinshi bya anthelminthique.Praziquantel numunyamoko ariko enantiomer ya R (+) ishinzwe gusa ibikorwa byayo birwanya antiparasitike.Irakora kurwanya trematode (ubwoko bwose bwa Schistosoma butera umuntu, Paragonimus westermani, na Clonorchis sinensis) na cestode (Taenia saginata, Taenia solium, Hymenolepis nana na Diphyllobothrium latum).
Uburyo bwibikorwa bya praziquantel ntabwo bizwi neza.Schistosomes ifata ibiyobyabwenge vuba.Kunywa ibiyobyabwenge bihita bikurikirwa no kongera ibikorwa byimitsi igenda igabanuka tetanic hamwe na vacuolisation ya parasite tegument.
Ingaruka yimitsi yibiyobyabwenge ifatwa nkinshingano zo guhindura parasite kuva mumitsi ya mesenteric yerekeza mwumwijima muri vivo.Ariko kandi, ihinduka ry’umwijima ryerekanwe na schistosomicide izwi cyane kandi ntishobora gutanga amakuru yihariye yukuntu imiti ikora.Ubushakashatsi buherutse gukorwa mu bushakashatsi bwerekanye ko ingaruka za antischistosomal z’imiti zifitanye isano n’ingaruka zayo kuri tegumenti aho kuba ku mitsi.
Iyindi ngaruka ya farumasi yibiyobyabwenge ikubiyemo kwiyongera kwa membrane yinjira muri cations, cyane cyane calcium.
Icyakora, uruhare rwiyi ngaruka kumitungo ya anthelminthique yibiyobyabwenge ntiramenyekana.
Gusaba
Nubwoko bwimiti yagutse irwanya parasitike.Irashobora gukoreshwa mu kuvura no gukumira schistosomiasis, cysticercose, paragonimiasis, indwara ya hydatide, fasciolopsiasis, indwara ya hydatide, n'indwara zangiza.
Irashobora kandi gukoreshwa nka anthelmintic kandi ifite akamaro mukuvura nematode yinyamanswa.Irashobora kuvangwa mubiryo byo gusaba.
Igicuruzwa ni ubwoko bwimiti igabanya ubukana mu kuvura Schistosoma japonicum, Schistosoma mansoni na Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms na cysticercose.Ifite ingaruka zikomeye zo kwica kuri tapeworm kandi kuri ubu ikora neza cyane mumiti irwanya schistosomiasis.
Nubwoko bwimiti ya anthelmintics ikoreshwa cyane mukuvura schistosomiasis.Irashobora kandi gukoreshwa mu kuvura Fahrenheit schistosomiasis, taeniasis, paragonimiasis, na cysticercose
