Ibisobanuro bigufi:
Numero ya CAS: 38821-53-3
Inzira ya molekulari: C16H19N3O4S
uburemere bwa molekile: 349.4
Imiterere ya shimi:
| Amakuru Yibanze | |
| Izina ryibicuruzwa | Cefradine |
| Igihagararo | Umucyo |
| Kugaragara | Ifu yera |
| Suzuma | 99% |
| Ingingo yo gushonga | 140-142 C. |
| Gupakira | 5KG; 1KG |
| Ingingo yo guteka | 898 ℃ |
Ibisobanuro
Cefradine (izwi kandi ku izina rya cephradine), 7- ene-2-karubasi ya acide monohydrate (111 ni igice cya sintetike cephalosporin antibiotic. ikoreshwa mu kanwa, mu mitsi, no mu mitsi. Imiterere ya cephradine isa n'iya cephalexine, itandukaniro ryonyine riri mu mpeta zigizwe n'abantu batandatu. Cephalexin ifite eshatu. imigozi ibiri ikora sisitemu ya aromatic mugihe cephradine ifite imigozi ibiri mumpeta imwe Igikorwa cya antibacterial ya cephradine isa niyya cephalexin[1].
Igishushanyo1 imiterere yimiti ya cefradine;
Cephradine ni ifu ya kirisiti yera ifite uburemere bwa 349.4[2]. Synthesis ya cephradine yaganiriweho[3]. Cephradine irashobora gushonga kubusa mumashanyarazi. Ni zwitterion, ikubiyemo itsinda rya alkaline amino na groupe acide acide. Muri pH urwego rwa 3-7, cephradine ibaho nkumunyu wimbere[4]. Cephradine ihagaze neza kumasaha 24 kuri 25 "murwego rwa pH ya 2-8. Kubera ko ihagaze neza mubitangazamakuru bya acide, nta gutakaza ibikorwa bike mumazi ya gastrica; byagaragaye ko igihombo kiri munsi ya 7%.[5].
Cephradine ihujwe cyane na poroteyine z'umuntu. Umuti wari munsi ya 20% uhujwe na poroteyine za serumu[4]. Kuri serumu yibanze ya 10-12 pg / ml, 6% yibiyobyabwenge byose byari murwego rwa poroteyine. Ubundi bushakashatsi[6]basanze ku gipimo cya 10 pg / ml, 28% by'ibiyobyabwenge byari muri poroteyine; ku gipimo cya 100 pg / ml, 30% by'ibiyobyabwenge byari muri poroteyine. Ubu bushakashatsi bwerekanye kandi ko kwiyongera kwa serumu kuri cephradine byagabanije ibikorwa bya antibiotique. Ubundi bushakashatsi[2]yerekanye ko poroteyine ihuza cephradine itandukanye kuva 8 kugeza 20%, bitewe nubunini bwibiyobyabwenge. Ariko, ubushakashatsi bwakozwe na Gadebusch n'abandi.[5]wasanze nta gihinduka muri MIC ya cephradine yerekeza kuri Staphylococcus aureus cyangwa Escherichia coli nyuma yo kongeramo serumu yabantu.
Ibyerekana
Cephradine ikora muri vitro irwanya ubwoko bwinshi bwa bagiteri-nziza na garama-mbi, harimo ibinyabuzima bitera indwara byitaruye ivuriro; urugimbu rwerekanwe ko rufite aside ihamye, kandi kongeramo serumu yabantu byagize ingaruka nke gusa kuburemere buke (MIC) kubinyabuzima byoroshye. Iyo cephradine itanzwe mu kanwa cyangwa mu buryo bwihuse ku nyamaswa zanduye mu buryo bw'igeragezwa na bagiteri zitandukanye zitera indwara, cephradine yatanze uburinzi bwiza[16]. Mu kuvura indwara zandura zanduye, ubushakashatsi bwakozwe ku mavuriro bushimishije ku buvuzi bwa cephradine bwatangajwe n’abashakashatsi benshi[14, 15, 17-19].
