Ibisobanuro bigufi:
Numero ya CAS: 472-15-1
Inzira ya molekulari: C.30H48O3
uburemere bwa molekile: 456.71
Imiterere ya shimi ：
| Amakuru Yibanze | |
| Izina ryibicuruzwa | Acide ya Betuline |
| Icyiciro | Icyiciro cya Farma |
| Kugaragara | Cyera cyangwa cyera |
| Suzuma | 98% |
| Ubuzima bwa Shelf | Imyaka 2 |
| Gupakira | 25kg / ingoma |
| Imiterere | Ihamye, ariko ubike neza. Ntibishobora kubangikanya imbaraga zikomeye za okiside, calcium gluconate, barbiturates, sulfate ya magnesium, fenytoin, vitamine B yo mu itsinda B. |
Ibisobanuro
Acide ya Betuline (472-15-1) ni Lupane triterpenoid isanzwe ikomoka ku giti cyera (Betula pubescens). Itera apoptose mumirongo itandukanye y'utugari.1 Itera mitochondrial permeability inzibacyuho ya pore ifungura.2? Gukora nka chemosensitizer yo kuvura imiti igabanya ubukana bwa kanseri ya kanseri ya kanseri ya kanseri.
Koresha
Acide ya Betuline ni pentacyclic triterpenoid. Acide Betulinic yerekana ibikorwa byo kurwanya inflammatory no kurwanya virusi itera sida. Acide Betulinic Acide itera apoptose mungirangingo yibibyimba ukoresheje inzira ya mito-iyambere ya apoptose ikoresheje uburyo bwigenga bwa p53- na CD95. Acide Betulinic irerekana kandi ibikorwa bya TGR5 agonist.
Acide ya Betuline (BetA) yakoreshejwe:
1.kugerageza ingaruka zayo nka antiviral anti-virusi ya Dengue (DENV).
2.nkuburyo bwa sterol igenga poroteyine (SREBP) inhibitor kugirango ihagarike metabolisme ya lipide no gukwirakwira kwingirangingo zimpyiko zifata kanseri (ccRCC).
3.nuburyo bwo gupima imiterere yabwo yo kurwanya ibibyimba kugirango ubuzima bwimikorere ya selile hamwe na apoptotique selile apfa muburyo bwinshi bwa myeloma.
Ubushakashatsi bwa Anticancer
Uru ruganda ni pentacyclic triterpene yakuwe mu bwoko bwa Betula na Zizyphus, bwerekana cytotoxicité ihitamo kurwanya selile ya melanoma ya muntu (Shoeb2006). Itanga ubwoko bwa ogisijeni ikora, ikora MAPK cascade, inhibitstopoisomerase ya I, ikabuza angiogenezi, igahindura imitekerereze ya transcriptionalactivator, igahindura ibikorwa bya aminopeptidase-N, bityo igatera indwara ya kanseri (Desai et al. 2008; Fulda 2008).
Igikorwa cyibinyabuzima
Kamere ya triterpenoid yerekana ibikorwa byo kurwanya virusi itera sida na antitumor. Bitera umusaruro wubwoko bwa ogisijeni ikora (ROS) kandi ikora NF- κ B. Yerekana ibikorwa bya agoniste TRG5 (EC 50 = 1.04 μ M).
Ibikorwa bya Biochem / physiol
Acide Betulinic, pentacyclic triterpene, ihitamo gutera apoptose mungirangingo yibibyimba ikora mu buryo butaziguye inzira ya mito-iyambere ya apoptose ikoresheje uburyo bwigenga bwa p53- na CD95.
