Ibisobanuro bigufi:
Numero ya CAS:51322-75-9
Inzira ya molekulari:C9H8ClN5S
uburemere bwa molekile:253.71
Imiterere ya shimi ：
| Amakuru Yibanze | |
| Izina ryibicuruzwa | Tizanidine |
| Icyiciro | Icyiciro cya Farma |
| Kugaragara | Ifu yera |
| Suzuma | 99% |
| Ubuzima bwa Shelf | Imyaka 2 |
| Gupakira | 25kg / ingoma |
| Imiterere | Ubike kuri -20 ° C. |
Urucacagu
Tizanidine ni imidazoline ikomoka kuri azote heterocyclic pentene ikomoka. Imiterere isa n'iya clonidine. Mu 1987, yashyizwe ku rutonde rwa mbere muri Finlande nka adrenalin yo hagati α2 reseptor agonist. Kugeza ubu, ikoreshwa nk'imitsi yo hagati yoroheje mu ivuriro. Irashobora gukoreshwa mu kuvura imitsi ibabaza imitsi, nka syndrome yo mu rukenyerero rwo mu ijosi na torticollis. Irashobora kandi gukoreshwa mu kuvura ububabare nyuma yo kubagwa, nka disiki ya herniation na arthrite. Iva muri ankylose yindwara zifata ubwonko, nka sclerose nyinshi, myelopathie idakira, impanuka yubwonko nibindi.
Imikorere
Ikoreshwa mukugabanya imitsi ya skeletale, spasm yimitsi na myotoniya iterwa no gukomeretsa ubwonko nu mugongo, kuva ubwonko bwubwonko, encephalite na sclerose nyinshi.
Imiti
Ihitamo kugabanya irekurwa rya aminide acide ishimishije muri interneurons kandi ikabuza uburyo bwinshi bwa synaptique bujyanye no kurenza imitsi. Ibicuruzwa ntabwo bigira ingaruka ku ikwirakwizwa rya neuromuscular. Ihangane neza. Ifite akamaro gakomeye kubabara imitsi kandi ankylose idakira ikomoka kumugongo no mubwonko. Irashobora kugabanya kurwanya kwimuka gusa, kugabanya spastitike na clonus, no kongera ubukana bwimikorere kubushake.
Gukoresha
Ikimenyetso cya Tizanidine, kigenewe gukoreshwa nkigipimo cyimbere cyo kugereranya Tizanidine na GC- cyangwa LC-mass spectrometry. Tizanidine irashobora gukoresha imiti nka SARS-CoV-2 protease inhibitor.
Gukoresha Ivuriro
Tizanidine ni adrenergic α2 reseptor agonist ikora hagati yo kuvura imitsi idakira, nka sclerose nyinshi.
Uburyo bwibikorwa
Tizanidine nigikorwa gikora hagati yimitsi yoroheje ya analon ya clonidine yemerewe gukoreshwa mukugabanya ubukana bujyanye no gukomeretsa ubwonko cyangwa umugongo. Uburyo bwibikorwa byo kugabanya ubukana bwerekana presinaptic kubuza moteri ya neuron kuriα2-adrenergic reseptors site, kugabanya irekurwa rya acide aminide ishimishije no kubuza inzira yoroshye ya ceruleospinal, bityo bigatuma kugabanuka kwinshi. Tizanidine ifite agace gato gusa k'igikorwa cyo kurwanya antivypertensique ya clonidine, birashoboka ko kubera ibikorwa kumurwi watoranijwe waα2C-adrenoeptors, bigaragara ko ishinzwe ibikorwa byo gusesengura no kurwanya antispasmodic ya imidazolineα2-agoniste (20).
