Ibisobanuro bigufi:
Numero ya CAS: 15687-27-1
Inzira ya molekulari: C13H18O2
Uburemere bwa molekile: 206.28
Imiterere ya shimi:
| Amakuru Yibanze | |
| Izina ryibicuruzwa | Ibuprofen |
| URUBANZA No. | 15687-27-1 |
| Ibara | Cyera kugeza cyera |
| Ifishi | Ifu ya Crystalline |
| Gukemura | Mubyukuri bidashobora gushonga mumazi, gushonga kubuntu muri acetone, muri methanol no muri chloride ya methylene. Irashonga mubisubizo bya hydroxide ya alkali na karubone. |
| Amazi meza | kutabasha |
| Igihagararo | Ihamye. Yaka. Ntibishobora kubangikanya imbaraga zikomeye za okiside |
| Ubuzima bwa Shelf | 2 Yugutwi |
| Amapaki | 25kg / Ingoma |
Ibisobanuro
Ibuprofen ni iy'umuti udasanzwe wa anti-inflammatory analgesic. Ifite anti-inflammatory, analgesic na antipyretic hamwe nibisubizo bibi. Yakoreshejwe cyane ku isi, nk'imiti igurishwa cyane ku isi itari imiti. Hamwe na aspirine na paracetamol byashyizwe ku rutonde rwibintu bitatu byingenzi birwanya imiti igabanya ubukana. Mu gihugu cyacu, ikoreshwa cyane cyane mu kugabanya ububabare no kurwanya rubagimpande, n'ibindi. Ifite uburyo buke mu kuvura ubukonje n’umuriro ugereranije na parasetamol na aspirine. Hariho amasosiyete menshi yimiti yujuje ibyangombwa byo gukora ibuprofen mubushinwa. Ariko igice kinini cyibicuruzwa byimbere mu gihugu bya ibuprofen byafashwe na Sosiyete ya Tianjin Sino-Amerika.
Ibuprofen yavumbuwe na Dr. Stewart Adams (nyuma aba umwarimu kandi yegukana umudari w'Ingoma y'Ubwongereza) n'itsinda rye barimo CoLinBurrows na Dr. John Nicholson. Intego yubushakashatsi bwambere kwari ugutegura "super aspirine" kugirango ibone ubundi buryo bwo kuvura rubagimpande ya rubagimpande igereranywa nki aspirine ariko ikagira ingaruka mbi zikomeye. Ku bindi biyobyabwenge nka phenylbutazone, bifite ibyago byinshi byo gutera adrenal guhagarika nibindi bintu bibi nka ibisebe byo munda. Adams yahisemo gushakisha imiti irwanya gastrointestinal nziza, ifite akamaro kanini kumiti yose itari steroidal anti-inflammatory.
Imiti ya fenyl acetate yatumye abantu bashimishwa. Nubwo bimwe muri ibyo biyobyabwenge byagaragaye ko bifite ibyago byo gutera ibisebe hashingiwe ku kizamini cy’imbwa, Adams azi ko iki kibazo gishobora guterwa n’ubuzima burebure buringaniye bwo gukuraho ibiyobyabwenge. Muri iki cyiciro cyibiyobyabwenge harimo ibice - ibuprofen, ifite ubuzima bucye ugereranije nigihe gito, ikomeza amasaha 2 gusa. Mu bindi biyobyabwenge byerekanwe, nubwo bidakorwa neza, ni umutekano cyane. Muri 1964, ibuprofen yari yarahindutse ibyiringiro byinshi kuri aspirine.
Ibyerekana
Intego rusange mugutezimbere imiti nububabare ni ugushiraho ibice bifite ubushobozi bwo kuvura umuriro, umuriro, nububabare bitabangamiye indi mirimo yumubiri. Kugabanya ububabare rusange, nka aspirine na ibuprofen, bibuza COX-1 na COX-2. Imiti yihariye ya COX-1 na COX-2 igena ingaruka zingaruka mbi. Imiti ifite umwihariko kuri COX-1 izaba ifite amahirwe menshi yo kubyara ingaruka mbi. Mugukuraho COX-1, kugabanya ububabare budatoranijwe byongera amahirwe yingaruka zitifuzwa, cyane cyane ibibazo byigifu nko kurwara igifu no kuva amaraso gastrointestinal. Inhibitori ya COX-2, nka Vioxx na Celebrex, ihitamo guhagarika COX-2 kandi ntigire ect COX-1 ku kigero cyagenwe. Inhibitori ya COX-2 yandikiwe cyane kurwara rubagimpande no kugabanya ububabare. Mu 2004, Ubuyobozi bushinzwe ibiryo n'ibiyobyabwenge (FDA) bwatangaje ko ibyago byinshi byo guhitanwa n'umutima ndetse n'indwara yo mu bwonko bifitanye isano na zimwe mu nzitizi za COX-2. Ibi byatumye ibirango byo kuburira no kuvana ku bushake ibicuruzwa ku isoko n’abakora ibiyobyabwenge; nk'urugero, Merck yakuye Vioxx ku isoko mu 2004. Nubwo ibuprofen ibuza COX-1 na COX-2, ifite inshuro nyinshi umwihariko kuri COX-2 ugereranije na aspirine, itanga ingaruka nke zo mu gifu..
