Cefoperazone sodium + sulbactam sodium

Ibisobanuro:
Cefoperazone sodium + sodium ya sulbactam (1: 1/2: 1) nigikorwa cyababyeyi, β-lactamase inhibitor iherutse kwerekanwa nkigicuruzwa cya 1: 1 hamwe na cefoperazone. Kimwe na acide clavulanic, agent ya mbere yubu bwoko yatangijwe, sulbactam yongerera imbaraga antibiyotike ya β-lactam kurwanya imiti irwanya.
Ikoreshwa:
Igice cya sintetike β-lactamase inhibitor. Ikoreshwa ifatanije na β-lactam antibiotique nka antibacterial.
Umunyu wa Cefoperazone sodium ni antibiyotike ya cephalosporine yo kubuza gufata rMrp2 yunganirwa [3H] E217βG hamwe na IC50 ya 199 μM. Intego: Antibacterial Cefoperazone ni sterile, semisintetike, yagutse cyane, antibiyotike ya cephalosporin y'ababyeyi kubuyobozi bwimitsi cyangwa imitsi. Nyuma yubuyobozi bwimitsi ya g 2 ya Cefoperazone, urwego rwa serumu rwatangiraga kuva 202μg / mL kugeza kuri 375 μg / mL bitewe nigihe cyo gucunga ibiyobyabwenge. Nyuma yo gutera inshinge 2 g ya Cefoperazone, urwego rwo hejuru rwa serumu ni 111 μg / mL mumasaha 1.5. Ku masaha 12 nyuma yo kunywa, bivuze ko serumu ikiri 2 kugeza 4 μg / mL. Cefoperazone ihuza 90% na poroteyine za serumu.