Ibisobanuro bigufi:
Numero ya CAS: 27164-46-1
Inzira ya molekulari: C14H15N8NaO4S3
uburemere bwa molekile: 478.5
Imiterere ya shimi ：
| Amakuru Yibanze | |
| Izina ryibicuruzwa | Umunyu wa sodium ya Cefazolin |
| URUBANZA No. | 27164-46-1 |
| Kugaragara | Ifu yera-Yera ifu ya kristaline |
| Icyiciro | Icyiciro cya Farma |
| Ububiko | Komeza ahantu hijimye, Inert ikirere, 2-8 ° C. |
| Ubuzima bwa Shelf | Imyaka 2 |
| Igihagararo | Birahamye, ariko birashobora kuba ubushyuhe - kubika mubihe byiza. Birashobora guhinduka ibara ryumucyo - kubika mwijimye. Ntibishobora gukoreshwa na okiside ikomeye. |
| Amapaki | 25kg / Ingoma |
Ibisobanuro ku bicuruzwa
Antibiyotike ya kimwe cya kabiri kirimo cephalosporine muri molekile ya cephalosporine. Byahinduwe nka Xianfeng mycin. ni β-Antibiyotike ya Lactam, yego β- Ibikomoka kuri aside 7-aminocephalosporanic (7-ACA) muri antibiyotike ya lactam ifite uburyo bwa bagiteri bwica. Ubu bwoko bwimiti burashobora gusenya urukuta rwa selile ya bagiteri no kubica mugihe cyimyororokere. Ifite ingaruka zikomeye zo guhitamo kuri bagiteri kandi hafi yuburozi kubantu, hamwe nibyiza nka antibacterial spécran, ingaruka zikomeye za antibacterial, kurwanya imisemburo ya penisiline, hamwe na allergique nkeya ugereranije na penisiline. Ni antibiyotike yingenzi kandi ikora neza, uburozi buke, hamwe nubuvuzi bugari. Igisekuru cya mbere cephalosporine yakozwe mbere, hamwe nibikorwa bikomeye bya antibacterial ugereranije na Chemical Book, antibacterial spectrée nini, hamwe ningaruka nziza za bagiteri nziza kurusha Gram mbi. Yakozwe na Staphylococcus aureus β- Lactamase irahagaze neza kandi irashobora kubuza umusaruro wa bagiteri mbi β- Lactamase ntigihungabana kandi irashobora gukorwa na bagiteri nyinshi za Gram mbi β- Yangijwe na lactamase. Sodium ya Cefazolin ni igice cya kabiri cyogukora cephalosporine igira ingaruka za antibacterial anti-bagiteri na bagiteri-mbi. Bikunze gukoreshwa mu kwanduza sisitemu y'ubuhumekero, sisitemu ya urogenital, uruhu rworoshye rw'uruhu, amagufwa hamwe n'ingingo, hamwe na biliary inzira iterwa na bagiteri zoroshye, ndetse no muri endocarditis, sepsis, pharyngeal na ugutwi. Ifite ibikorwa bikomeye birwanya bagiteri-nziza nka Staphylococcus aureus na Streptococcus (ukuyemo Enterococcus), kandi iruta igisekuru cya gatatu cephalosporine.
Gukoresha imiti
Cefazolin (Ancef, Kefzol) ni rumwe mu ruhererekane rwa semisyntheticcephalosporine aho imikorere ya C-3 ya acetoxy yasimbuwe na heterocycle ya thiol-hano, 5-methyl-2-thio-1,3,4-thiadiazole. Irimo kandi tetrazolylacetyl acylating group runaka. Cefazolin yarekuwe mu 1973 nk'umunyu wa sodium ushonga. Nibikorwa byubuyobozi bwababyeyi.
Cefazolin itanga serumu nyinshi, gahoro gahoro gahoro, hamwe nubuzima burebure burenze iyindi generation-yambere ya cecephalosporine. Ni hafi ya 75% bya poroteyine ihujwe na inplasma, agaciro karenze ugereranije nizindi cephalosporine nyinshi. Mbere mubushakashatsi bwa vitro nubuvuzi bwerekana ko cefazolin idakora cyane kurwanya Gram-negative bacilli ariko ntigikora cyane Gram-positif cocci kuruta cephalothine orcephaloridine. Igipimo cyibibaho bya trombophlebitis nyuma yo guterwa no gutera inshinge hamwe nububabare aho intramuscularinjection bigaragara ko aribwo hasi cyane ya parenteralcephalosporine.
