Ibisobanuro bigufi:
Numero ya CAS:590-63-6
Inzira ya molekulari:C7H17ClN2O2
uburemere bwa molekile:196.68
Imiterere ya shimi ：
| Amakuru Yibanze | |
| Izina ryibicuruzwa | Bethanechol |
| Icyiciro | Icyiciro cya Farma |
| Kugaragara | ifu yera |
| Suzuma | 95% |
| Ubuzima bwa Shelf | Imyaka 2 |
| Gupakira | 25kg / ingoma |
| Imiterere | Ahantu hakonje kandi humye |
Ibisobanuro
Bethanechol ni estetique ya estterique muburyo bwa farumasi bijyanye na acetylcholine. Buhoro buhoro hydrolyzed muscarinic agonist nta ngaruka za nikotinike, bethanechol ikoreshwa muburyo bwo kongera imitsi yoroshye, nko mubice bya GI nyuma yo kubagwa inda cyangwa kubika inkari mugihe nta nkomyi. Irashobora gutera hypotension, ihinduka ryumutima, hamwe na spasms ya bronchial.
Bethanechol ni agoniste ya reseptor ya muscarinic acetylcholine ifite IC50 ifite agaciro ka 1.837, 25, 631, 317, na 393 μM kuri M1-5, muburyo bwa radioligand ihuza ibice ukoresheje selile CHO zerekana abantu. Irabuza M2-yunganirwa kwiyongera muri cyclic AMP iterwa na isoproterenol mu ngurube yitaruye amara mato mato (IC50 = 127 μM). Bethanechol yongerera ijwi ryibanze rya urecine yonyine (EC50 = 4.27 μM). Itera kandi gusohora amazi muri ileum, duodenum, na jejunum yimbeba zatewe aneste iyo itanzwe ku kigero cya 60 μg / kg. Imiti irimo bethanechol yakoreshejwe mu kongera inkari no kunoza imitsi yoroshye mu nzira ya gastrointestinal.
Gukoresha Ivuriro
Ikoreshwa ryingenzi rya bethanechol chloride ni mukorohereza kugumana inkari no guta inda nyuma yo kubagwa. Uyu muti ukoreshwa mu kanwa no mu gutera inshinge. Itmust ntizigera itangwa na intramuscular cyangwa intravenousinjection kubera akaga ka cholinergic kurenza urugero no gutakaza ibikorwa byatoranijwe. Gucunga neza ibiyobyabwenge bifitanye isano n'uburozi buke kandi nta ngaruka zikomeye. Chloride ya Bethanechol igomba gukoreshwa mwitonze abarwayi badafite imiti; iyo ikoreshejwe kuri glaucoma, itanga umutwe wimbere uhereye kumitsi ya sphinctermuscle mumaso no kuva mumitsi ya ciliary. Igihe cyacyo cyo gukora ni isaha 1.
Ibiyobyabwenge byamatungo nubuvuzi
Mu buvuzi bw'amatungo, bethanechol ikoreshwa cyane cyane mu gukurura uruhago mu nyamaswa nto. Irashobora kandi gukoreshwa nka esophageal cyangwa rusange itera imbaraga za GI, nubwo metoclopramide na / cyangwa neostigmine ahanini yabisabye kubikoresha.
